John H. Marburger III, former president of Stony Brook University and director of the Office of Science and Technology Policy (OSTP) under President George W. Bush, played a pivotal role in shaping the National Nanotechnology Initiative (NNI). Celebrating its 20th anniversary, the NNI marked the signing of the 21st Century Nanotechnology Research and Development Act. Marburger's leadership from 2001 to 2009 coincided with the formative years of the NNI, showcasing his foresight in anticipating technological advancements like Quantum Information Science. As part of the anniversary, the National Nanotechnology Coordination Office released reports highlighting NNI's impact, including advancements in microchips, mRNA vaccines, clean energy, and quantum computing. Marburger's legacy includes significant contributions to nanoscale science and engineering, fostering the NNI's enduring success.