Mrinank Sharma, head of Anthropic's safeguards research team, has resigned, citing a "threshold" of interconnected crises in a deeply philosophical letter shared on X. He warns that humanity's technical capabilities are outpacing moral foresight, highlighting concerns about AI's impact on humanity. Sharma's departure follows the launch of Claude Opus 4.6 and raises questions about Anthropic’s internal culture, particularly how values are upheld amid competitive pressures. His resignation adds to a wave of recent high-profile exits.