North America remains the world's leading startup region, home to 50% of the top 30 global ecosystems and deploying around $31.4 billion of investment in the third quarter of this year. However, if you're a no-name in the American market, you may struggle to raise funds or find an audience. To succeed, consider moving to the right business hub, not just top ecosystems like Silicon Valley, New York City, or Boston. The U.S. launched the Regional Technology and Innovation Hubs (Tech Hubs) competition in May 2023 to develop local centers of innovation and job creation. Some hubs worth considering include Detroit (industry and robotics), the Research Triangle in North Carolina (tech and life sciences), Minneapolis (finance and insurance), Houston (health, hospitality, and manufacturing), and Phoenix (SaaS, cybersecurity, and marketing). Approach locals through a VC with a network and consider team building, lawyers, accountants, and auditors.