Small and medium-sized enterprises (SMEs) are crucial for job creation and economic upliftment, especially in South Africa where high unemployment is prevalent. However, many fail within the first two years without significant support. To unlock sustainable growth, stronger collaboration between corporate South Africa and SMEs is needed. Key factors include digital transformation, energy sufficiency, sustainability, township economy, and skills development. Digital transformation can improve operations, margins, and customer value by leveraging cloud computing, data analytics, and AI. Energy sufficiency can be achieved through renewable energy solutions, efficiency-saving measures, and technology. Sustainability can lead to lower operational costs, reduced business risk, and new opportunities with a growing customer base. The township economy presents opportunities for SMEs to expand, diversify markets, and deliver additional product needs.