Mayo Clinic, recognizing the need for both physical and digital transformation in healthcare, devised a comprehensive strategy to modernize its facilities. Led by a team, they envisioned future states and crafted digital imperatives. By 2028, one new facility and by 2030, five fully operational buildings are planned, totaling 2.4 million square feet. These constructions emphasize digital capabilities, sustainability, and flexibility to adapt to evolving care models. The focus is on human-centered care, leveraging technology for personalized experiences, including robotics and systems integration. Beyond patient benefits, the initiative aims to enhance staff experiences and contribute to the community through job creation. This holistic transformation underscores Mayo Clinic's commitment to advancing healthcare both locally and globally.